Know the difference, make a difference

for women with aortic stenosis.§


Give your patients with symptomatic severe aortic stenosis (ssAS) the valve performance‡ advantages of Medtronic Evolut™ TAVR.1


Exclamation icon Indications, Safety, and Warnings
Evolut FX+ TAVR was not used within the SMART Trial.
TAVR risks may include, but are not limited to, death, stroke, damage to the arteries, bleeding, and need for permanent pacemaker.

Timely treatment is critical for survival.


Failure to seek timely treatment for ssAS is a problem that can cost patients their lives. If left untreated, once severe symptoms develop, average patient survival is just 50% at 2 years.2


Once severe symptoms begin, survival is cut short2


Treating aortic stenosis graphic

Detecting aortic stenosis in women can be more challenging.


Diagnosing ssAS can be more challenging in women compared to men, because their symptoms appear differently, and the severity is more frequently underestimated.3,4 Review the common diagnostic challenges of ssAS and identify strategies to improve treatment effectiveness.


Diagnostic challenges
Older couple on a bench seat Women with ssAS face a higher risk of mortality than men at the same age.
Woman are up to
less likely to be treated for TAVR or SAVR.6

Help close the treatment gap for women with aortic stenosis.


When it comes to heart valve disease, research shows that aortic stenosis (AS) impacts women differently than men, which must be addressed to ensure timely treatment and save lives.3,4

Smart trial logo

The SMART Trial makes a difference.


The SMART Trial is the largest, most rigorous trial to date, to randomize patients to the two most widely used TAVR devices, and the largest TAVR trial to enroll predominantly women.1


Not all TAVRs are the same.



The SMART Trial enrolled 87% women1

SMART Trial findings


When TAVR is the best option, it can make a difference in overall health outcomes. Based on the initial SMART results, the data points to Evolut™ TAVR — proven for women.†,1,7,8

Evolut™ TAVR delivers superior valve performance‡ in women with a small annulus at one year versus SAPIEN™* platform.1
BVD in women vs. SAPIEN™ platform bar graph
5x less

BVD‡ in women

vs. SAPIEN™ platform at
one year p < 0.001.1

BVD is bioprosthetic valve dysfunction.


TAVR risks may include, but are not limited to, death, stroke, damage to the arteries, bleeding, and need for permanent pacemaker.

Evolut™ TAVR Valve Performance

Performance matters


Sustained valve performance, as defined as freedom from bioprosthetic valve dysfunction (BVD◊), helps keep your patients alive and out of the hospital.9

If women do receive TAVR treatment, they have superior valve performance‡ compared to the SAPIEN™* platform at 1 year, based on results from the SMART trial.1


Learn more about valve performance Arrow icon

TAV
Evolut FX+ TAVR was not used within the SMART Trial.

Evolut™ TAVR has a differentiated design.


Built on the original CoreValve™ platform, Evolut™ TAVR is engineered with specific design elements to promote sustained valve performance with consistently large EOAs and low gradients over time.10,11


Durability starts with design.

1Supra annular positioning

2Nitinol frame

3Four times larger windows

4External tissue wrap

Evolut™ TAVR differentiated design that matters for your patient

You’ve chosen TAVR, now choose Evolut™

Valve performance‡ matters from day one.
Evolut™ TAVR delivers superior valve performance‡ in women with small annuli at 1 year vs. SAPIEN™* platform.1
Valve selection matters. Evolut™ TAVR – proven for women.†,1,7,8
TAVR risks may include, but are not limited to, death, stroke, damage to the arteries, bleeding, and need for permanent pacemaker.

Valve performance starts the day of the procedure and continues for a lifetime.

Give your ssAS patients a proven treatment option. When you believe TAVR is the best choice for your patients, you may not be thinking of a particular valve. Maybe you should be.


Explore durability

Valve performance

Find a Heart Team with Evolut™ TAVR experience.

Heart icon

The right Heart Team can make a difference.


Compared to the SAPIEN™* TAVR valve, Evolut™ TAVR demonstrated significantly better VARC-3∆ ordinal outcomes for quality of life at 12 months.1 Give your TAVR patients, especially women, the chance to benefit from a Heart Team experienced with Evolut™ TAVR.


Find an Evolut™ TAVR Experienced Heart Team

Additional resources.

Resources icon

Patient Education Resources


Provide your patients with educational resources that will help them better understand their ssAS and TAVR as a potential treatment option.


Download TAVR Discussion Guide Arrow icon

TAVRforWomen.com Arrow icon

† Based on the 1-year follow-up results from the SMART clinical trial which showed differences in valve performance‡ for Evolut compared to SAPIEN* and no differences in safety outcomes. SMART primarily studied small annulus patients, predominantly women.1 Additional clinical trials on women, regardless of their annulus size, have shown comparable mortality rates in women and men treated with TAVR7 and lower mortality rates for women treated with TAVR compared to women treated with surgical valve replacement8 at 1 year after the procedure.

‡ Valve performance as defined as freedom from bioprosthetic valve dysfunction (BVD) through 12 months. BVD is defined as a composite including any of the following: hemodynamic structural valve dysfunction (mean gradient ≥ 20 mmHg), non-structural valve dysfunction (severe prothesis-patient mismatch or ≥ moderate aortic regurgitation), clinical thrombosis, endocarditis, and aortic valve reintervention.

§ Evolut TAVR is indicated to treat patients who have been diagnosed with symptomatic severe aortic stenosis.

◊ Bioprosthetic Valve Dysfunction12 (BVD) defined as: SVD (mean gradient ≥ 10 mm Hg increase from 30-day/discharge to last echo AND ≥ 20 mm Hg at last echo or new onset/ increase of ≥ moderate intraprosthetic aortic regurgitation), NSVD (severe PPM at 30-day/discharge or severe PVR through 5 years), clinical valve thrombosis, and endocarditis.

¶ In patients with small annuli (area ≤ 430 mm2) in all-comers trial, consisting of majority low surgical risk participants (52.1%).

∆ VARC-3 ordinal outcome: (i) death; (ii) worsened: decrease from baseline >5 points; (iii) no change: change between -5 and <5 points; (iv) mildly improved: increase between 5 and <10 points; (v) moderately improved: increase between 10 and <20 points; (vi) substantially improved: increase ≥20 points.


  1. Tchétché D, Mehran R, Blackman DJ, et al. Transcatheter Aortic Valve Implantation by Valve Type in Women With Small Annuli: Results From the SMART Randomized Clinical Trial. JAMA Cardiol. Published online October 9, 2024.
  2. Ross J Jr, Braunwald E. Aortic stenosis. Circulation. July 1968;38(1 Suppl):61-67.
  3. Nau DP , Ellis JJ , Kline-Rogers EM, Mallya U, Eagle KA, Erickson SR. Gender and perceived severity of cardiac disease: evidence that women are “tougher.” Am J Med. November 2005;118(11):1256–1261.
  4. Iribarren AC, AlBadri A, Wei J, et al. Sex differences in aortic stenosis: Identification of knowledge gaps for sex-specific personalized medicine. Am Heart J Plus. September 2022;21:100197.
  5. Tribouilloy C, Bohbot Y, Rusinaru D, et al. Excess Mortality and Undertreatment of Women With Severe Aortic Stenosis. J Am Heart Assoc. January 5, 2021;10(1):e018816 
  6. Rice CT, Barnett S, O’Connell SP, et al. Impact of gender, ethnicity and social deprivation on access to surgical or transcatheter aortic valve replacement in aortic stenosis: a retrospective database study in England. Open Heart. September 2023;10(2):e002373.
  7. Forrest, J.K., et al., Transcatheter Aortic Valve Replacement in Women Versus Men (from the US CoreValve Trials). Am J Cardiol, 2016. 118(3): p. 396-402.
  8. Skelding, K.A., et al., Transcatheter Aortic Valve Replacement Versus Surgery in Women at High Risk for Surgical Aortic Valve Replacement (from the CoreValve US High Risk Pivotal Trial). Am J Cardiol, 2016. 118(4): p. 560-6.
  9. Yakubov SJ, Van Mieghem NM, Oh JK, et al. Impact of Transcatheter or Surgical Aortic Valve Performance on 5-Year Outcomes in Patients at ≥ Intermediate Risk. J Am Coll Cardiol. April 8, 2025;85(13):1419–1430.
  10. Herrmann HC. SMART 2-year data update. Presented at: CRT 2025; March 9, 2025; Washington, D.C.
  11. Forrest JK, Yakubov SJ, Deeb GM, Gada H, Mumtaz MA, Ramlawi B, Bajwa T, Crouch J, Merhi W, Wai Sang SL, Kleiman NS, Petrossian G, Robinson NB, Sorajja P, Iskander A, Berthoumieu P, Tchétché D, Feindel C, Horlick EM, Saito S, Oh JK, Jung Y, Reardon MJ; Low Risk Trial Investigators. J Am Coll Cardiol. 2025 Mar 21:S0735-1097(25)05335-5. Epub ahead of print​
  12. Adapted from VARC-3: Généreux P, Piazza N, Alu MC, et al. Valve Academic Research Consortium 3: updated endpoint definitions for aortic valve clinical research. J Am Coll Cardiol. 2021;77(21):2717–2746.

™* Third-party brands are trademarks of their respective owners. All other brands are trademarks of a Medtronic company.